Methadone is administered for relief of pain in horses, dogs and cats.

Use the contents within 28 days of first broaching of the vial. Discard the unused portion.

Horses:

Analgesia: 0.22 mg/kg (10 mL/450 kg) bodyweight by intramuscular or subcutaneous injection.

Restraint: 0.11 mg/kg (5 mL/450 kg) bodyweight combined with 0.055 mg/kg bodyweight acetylpromazine (2.5 ml of 10 mg/ml acetylpromazine per 450 kg) by intravenous injection. 

Dogs:

Analgesia: 0.11 - 0.55 mg/kg (0.11 - 0.55 mL/10 kg) bodyweight by intramuscular or subcutaneous injection.

Premedication: 1.1 mg/kg (1.1 mL/10 kg) bodyweight by subcutaneous injection. 

Cats:

Analgesia: 0.2 - 0.6 mg/kg (0.2 - 0.6 mL/10 kg) bodyweight by subcutaneous injection.

Premedication: 0.2- 0.6 mg/kg (0.2 - 0.6 mL/10 kg) bodyweight by subcutaneous injection.

Repeat analgesia: 0.2 - 0.6 mg/kg (0.2 - 0.6 mL/10 kg) bodyweight by subcutaneous injection at 3 time points with 5 hour intervals.